Serum Uric Acid Unrelated to Cancer Incidence in Humans1

We examined the hypothesis that low levels of serum uric acid are associated with elevated cancer risk. A subpopulation (163,830 members) of a large health maintenance organization was followed for a mean of 9.8 years after a multiphasic health checkup at which serum uric acid level was measured. Total cancer incidence as well as site-specific inci dence (for lung, colon, and prostate cancer in men and lung, colon, breast, uterine, and cervical cancer in women) was ascertained from hospital discharge records and the Surveillance, Epidemiology and End Results program in the San Francisco-Oakland Bay area. Age-adjusted cancer incidence was not elevated in the lower deciles of serum uric acid level. After adjusting for age, race, education, smoking, alcohol consumption, and body mass, using proportional hazards models, the risk of cancer was not elevated at lower levels of uric acid. Our results suggest that if increased risk of cancer is associated with low serum uric acid, this risk is associated with serum uric levels below those commonly seen in human populations.